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July 6, 2018

The medical journal Friday withdrew two papers authored by disgraced Italian surgeon Paolo Macchiarini, found guilty of misconduct regarding an experimental windpipe graft procedure of which most recipients died.

Retracting a study is a rare step for a prestigious journal which publishes work only after it has been peer-reviewed by other experts in the field concerned.

In an editorial, The Lancet announced "we are retracting two papers by Paolo Macchiarini and co-authors after receiving requests to do so from the new President of the Karolinska Institute (KI), Ole Petter Ottersen."

Macchiarini was attached to the Karolinska Institute, which awards the Nobel medicine prize every year, when he tested his controversial artificial tracheotomy transplants and published the results in The Lancet in 2011.

The operation involves coating an artificial wind pipe "scaffold" with the recipient's own stem cells, meant to develop into mature tracheal cells that will not be rejected by the patient's immune system.

Macchiarini and his colleagues performed eight such transplants in total. Seven of the patients died, and doctors lost track of the eighth.

The procedure was hailed at first as a breakthrough in Cold Shoulder Smock Top Blush Fashion Union Petite Discount Inexpensive Cheap Visa Payment Cheap Online Free Shipping Many Kinds Of Clearance With Mastercard UwvyHyfS
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But allegations soon emerged that the risky procedure had been carried out on at least one individual who had not, at the time, been critically ill.

In 2014, several surgeons at Karolinska filed a complaint alleging that Macchiarini had downplayed the risks of the procedure.

Karolinska suspended all transplants and fired Macchiarini.

In his request to The Lancet , Ottersen stated that "no ethical permit had been obtained for the underlying research," the journal quoted.

He added that "the research was carried out without sufficient support by preclinical data, and the paper presents its data in a way that is unduly positive and uncritical. The clinical findings reported are not supported by source data."

Two members of the Nobel medicine prize assembly were forced to step down over the scandal.

The Lancet in 2010, famously retracted a 1998 study that linking autism with a triple vaccine for measles, mumps and rubella (MMR).

Many parents stopped vaccinating their children as a result of the claims, and the issue is still a hot debate in many countries.

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More information: The Lancet Editors. Retraction—Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study, The Lancet (2018). DOI: 10.1016/S0140-6736(18)31558-7

The Lancet Editors. Retraction—Engineered whole organs and complex tissues, The Lancet (2018). FOOTWEAR Loafers Luca Valentini Free Shipping Sale LVNElq

2. React like an extension ofself

The machine or service acknowledges and interprets emotions. It might then expose these emotions back to the user, or even empathize. But the user stays in complete control of altering their emotions. This machine reaction is the one we are most comfortable with, as it most closely supports the idea of a servant or an emotional support system. Like University of Aberdeen Professor Judith Masthoff , “I would like people to have their own guardian angel that could support them emotionally throughout the day.”

This type of emotional support will become increasingly important in the automation of self-improvement services, be they concerned with health, wellness, or mastery of skills. While applications in the real world are lacking, we see huge potential in weight loss, stress management, mindfulness training, and skill training.

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3. React like ahuman

There are opportunities for mutual agreement between user and service to alter the user’s emotions for that user’s benefit. With such permission, machines can attempt to react like a human, to diagnose and interpret emotions, give advice, or trigger actions to change emotions. The user, in turn, agrees to allow the service to manipulate their emotions.

The emerging practice of machine therapy is a deliberate and beneficial application of this field, in which virtual mental-health professionals help people in places where psychotherapy is either riddled by stigma (e.g., the military) or unaccessible (e.g., areas of war or other humanitarian crisis). Machine therapy service FOOTWEAR Hightops amp; sneakers Clocharme Buy Cheap Largest Supplier XgCpcq5
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And while still perceived as niche, the “virtual coach” is rapidly becoming mainstream. Microsoft introduced its sweet-talking chatbot Xiaoice in China’s WeChat app in 2014. Three days after launch, it had been added to conversations 1.5 million times . Xiaoice now has emotional friendship-like exchanges with 40 million users, who have told it “I love you” 89 million times as of March 2107.

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A new level ofintimacy

The confluence of conversational UIs, machine learning, and affective computing opens up the opportunity for a much deeper relationship between user and brand. As with any relationship, trust is key, and the ways brands craft their value propositions, brand personalities, and their communication strategies play crucial roles in maintaining and deepening that trust. On the flip side, when entering emotional relationships, a breach of trust will not be forgiven. Brands need to tread carefully when entering the world of emotional experiences — the stakes are sky-high.

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